Lecture Notes

Rhabdomyolysis is the breakdown of skeletal muscle tissue, resulting in the release of muscle cell contents, including myoglobin, into the bloodstream. Myoglobinuria refers to the presence of myoglobin in urine, which can cause dark-colored urine and is often linked to rhabdomyolysis. This condition can have a wide range of causes and potentially fatal complications if not addressed promptly.

Potential Complications

• Acute Renal Failure: Myoglobin can obstruct renal tubules, leading to kidney damage.
• Cardiac Arrhythmias: Hyperkalemia (elevated potassium) from muscle breakdown affects heart rhythm.
• Respiratory Insufficiency: Weakness or failure of respiratory muscles.
• Bulbar Muscle Dysfunction: Affecting speech and swallowing.
• Encephalopathy: Due to metabolic disturbances.

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