Diffuse Neuronal Migration Disorders

Lissencephalies Overview

  • Human fetal brain initially has a smooth (agyric) surface.
  • Failure of gyral development leads to neuronal migration disorders: lissencephaly continuum.
  • Two major types:
    • Type 1: Under-migration of neurons.
    • Type 2: Over-migration of neurons.
  • Less common forms:
    • Lissencephaly with cerebellar hypoplasia (LCH)
    • X-linked lissencephaly (XLIS)
    • X-linked lissencephaly with ambiguous genitalia (XLAG)
    • Micro-lissencephaly
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Information
Published:01 May 2025
Modified: 01 May 2025